IIS Error - he system cannot find the file specified _找不到页面

World Wide Web Publishing in services does not start,start it.

We have been experiencing intermittent shut downs of IIS which have now culminated in an unstartable instance resulting in Error 2 each time we try to start the service. We had some NTFS errors previously (possible effect on permissions), and have attempted the reset of IIS several times with no results.

I have read some posts here on EE that point to permissions for the system user, and to IWAM and IUSR but none of those permissions have been changed by human hands on this box. We are getting ready to uninstall/reinstall IIS but wondering if there is anything else we should try.